Go to Course: https://www.coursera.org/learn/targets-assays-screening
Promising compounds used in the hunt for novel drugs. Types of assays & methods used to screen molecule libraries. Methods for hit validation.
Targets, Assays & Screening, part 1
Welcome, by the end of the course students will be able to: Recognize the differences between target-based and phenotypic drug discovery. Differentiate between common library types and screening approaches for identifying small molecule hits. Describe some of the assay types used in early screening and factors to consider in their design.
Targets, Assays & Screening, part 2Targets, Assays & Screening, part 3This course focuses on the early stages of drug discovery and the identification of promising compounds with which to begin the hunt for a novel drug. Different types of assays and methods are reviewed that are used to screen libraries of molecules in the preliminary search for compounds with activity. Methods are discussed for validating that active molecules are indeed engaging a target associated with a predicted therapeutic benefit. Target audience: This course is suitable for life scien