Go to Course: https://www.coursera.org/learn/lead-selection-optimization
Lead Selection & Optimization, part 1
Welcome, by the end of the course students will be able to: Recognize malaria as a neglected tropical disease and understand its significance as an unmet medical need. Identify and describe some of the characteristics an effective small molecule therapeutic should possess, and liabilities to avoid. Describe the principles and common approaches used in defining and optimizing a lead compound's pharmacophore.
Lead Selection & Optimization, part 2Lead Selection & Optimization, part 3This course covers the stages of drug discovery in which promising compounds (leads) are identified, their optimal and suboptimal characteristics determined, and the suboptimal characteristics optimized to create a candidate suitable for the clinic. The course is built around a case study on the discovery of an antimalarial therapy. Assays useful for screening new compounds are outlined, examples of selection criteria for leads are discussed - such as potency, efficacy, and pharmacokinetics -
Key concepts covered in a concise and accessible format.
It is a perfect course with ample knowledge and testing of knowledge by quizzes and discussions.